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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T79474 | GSPT1 degrader-1 | Apoptosis | |
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1]. | |||
T41257 | SJ6986 | Others | |
SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1]. | |||
T82253 | GSPT1 degrader-2 | ||
GSPT1 degrader-2 is a potent degrader of GSPT1 [1]. | |||
T33380 | MI-389 | PROTACs | |
MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1). | |||
T78986 | MDEG-541 | c-Myc | |
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1]. | |||
T79139 | GBD-9 | PROTACs | |
GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecu... | |||
T74994 | SJ988497 | PROTACs | |
SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker... |