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Search Results for " gspt1 degrader-1 "

7

Compounds

Cat No. Product Name Synonyms Targets
T79474 GSPT1 degrader-1 Apoptosis
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].
T41257 SJ6986 Others
SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1].
T82253 GSPT1 degrader-2
GSPT1 degrader-2 is a potent degrader of GSPT1 [1].
T33380 MI-389 PROTACs
MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T78986 MDEG-541 c-Myc
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].
T79139 GBD-9 PROTACs
GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecu...
T74994 SJ988497 PROTACs
SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker...
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